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Flow Cytometry’s Role in T-Cell Lymphoma

Leuk Lymphoma; ePub 2016 Apr 22; Loghavi, et al

Multiparameter flow cytometry can help diagnose angioimmunoblastic T-cell lymphoma (AITL) in a variety of fluids and tissue specimen types, according to a study involving 38 individuals.

Investigators used 155 samples from the participants, all of whom had AITL. Among the results:

• Flow cytometry identified an aberrant T-cell population in 97 samples (from 16 patients) that represented 0.5% to 90% of lymphocytes.

• Blood was involved in 11 of the 16 patients.

• The most frequent immunophenotypic aberrancies: loss of CD3; altered T-cell receptor expression; and aberrant CD10 expression.

• Altered CD3 was more frequently observed in peripheral blood and bone marrow.

• Aberrant CD10 was more common in lymph nodes.

Citation: Loghavi S, Wang S, Medeiros J, et al. Immunophenotypic and diagnostic characterization of angioimmunoblastic T-cell lymphoma by advanced flow cytometric technology. [Published online ahead of print April 22, 2016]. Leuk Lymphoma. doi:10.3109/10428194.2016.1170827.