Early T-cell precursor (ETP) acute lymphoblastic leukemia/lymphoma (ALL/LBL) is a high-risk subtype of adult ALL, according to a study involving 111 individuals.
Investigators compared how adults with ETP-ALL/LBL who received treatment on frontline regimens fared vs those with other T-ALL/LBL immunophenotypic subtypes. Patients were categorized into early, thymic, and mature subgroups. Among the results:
• Outcomes were the same regardless of subtypes.
• 19 patients had ETP-ALL/LBL.
• Rate of complete remission with or without complete platelet recovery rate in these individuals was 73%, vs 91% in those with non–ETP-ALL/LBL.
• Median overall survival was 20 months in patients with ETP-ALL/LBL, vs not reached in non–ETP-ALL/LBL patients.
Citation: Jain N, Lamb A, O’Brien S, et al. Early T-cell precursor acute lymphoblastic leukemia/lymphoma (ETP-ALL/LBL) in adolescents and adults: A high-risk subtype. Blood. 2016;127(15):1863-1869. doi:http://dx.doi.org/10.1182/blood-2015-08-661702.