Key clinical point: A high preoperative plated-lymphocyte ratio is correlated with poor prognosis in patients with renal cell carcinoma.
Major finding: Subgroup analysis revealed that a high preoperative plated-lymphocyte ratio significantly predicted worse overall survival and progression-free survival in metastatic RCC patients receiving mixed therapies (OS, pooled HR = 3.69, 95% CI: 1.93–11.42, p = 0.023; PFS, pooled HR = 6.05, 95%CI: 1.34–27.37, p = 0.019) and targeted therapy (OS, pooled HR = 1.59, 95%CI: 0.97–2.62, p = 0.067).
Study details: A literature search from PubMed, Embase, Web of Science and Cochrane database to evaluate the relationships between preoperative plated-lymphocyte ratio and prognosis in RCC patients found a total of 1528 patients from seven studies.
Disclosures: The researchers had no relevant financial disclosures.
Wang Z et al. Clinica Chimica Acta; 2018; 480: 166-72.