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Pathologic predictors in lymph node dissection of metastatic RCC

Chipollini J et al. Clinical Genitourinary Cancer 2018; 16: Pages e443-450.

Key clinical point: For patients with metastatic renal-cell carcinoma undergoing cytoreductive nephrectomy with lymphadenectomy, the number of nodes positive was predictive of survival at short-term follow-up.

Major finding: Nodal involvement (pN+) was seen in 106 patients with a median cancer-specific survival of 11.3 months (95% confidence interval [CI], 6.6, 15.9) versus 24.2 months (95% confidence interval, 14.1, 34.3) for pN− patients (log-rank P = .002). The hazard ratio for lymph node dissection was 1.325 (95% CI, 1.002, 1.75) for the whole cohort and 1.024 (95% CI, 0.682, 1.537) in the propensity score–matched cohort. Multivariate analysis revealed that number of positive lymph nodes (P < .001) was a significant predictor of worse cancer-specific survival .

Study details: 293 consecutive patients treated with cytoreductive nephrectomy at 4 academic institutions from March 2000 to May 2015. Lymph node dissection was performed in 187 (63.8%).

Disclosures: The researchers had no relevant financial disclosures.

Citation:

Chipollini J et al. Clinical Genitourinary Cancer 2018; 16: Pages e443-450.