Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Partial vs Radical Nephrectomy Impact on Survival

Eur Urol Focus; ePub 2018 Feb 2; Marchioni, et al

Partial nephrectomy (PN) may help prevent renal insufficiency, hypertension, and other unfavorable health outcomes in older people with nonmetastatic T1a renal cell carcinoma (RCC), according to a study involving >4,500 individuals. Participants were ≥75 years of age with surgically-treated nonmetastatic T1a RCC. Investigators looked at the impact partial vs radical nephrectomy had on other-cause, cancer-specific, and 30-day mortality. Among the results:

  • 42% of patients had partial nephrectomy.
  • Those undergoing partial nephrectomy were 33% less likely than those who had radical nephrectomy to experience other-cause mortality.
  • The favorable outcome was seen across all ages evaluated.
  • Those in the partial nephrectomy group were 36% less likely to experience cancer-specific mortality.
  • 30-day mortality rates did not differ.


Marchioni M, Preisser F, Bandini M, et al. Comparison of partial versus radical nephrectomy effect on other-cause mortality, cancer-specific mortality, and 30-day mortality in patients older than 75 years. [Published online ahead of print February 2, 2018]. Eur Urol Focus. doi:10.1016/j.euf.2018.01.007