Partial nephrectomy (PN) may help prevent renal insufficiency, hypertension, and other unfavorable health outcomes in older people with nonmetastatic T1a renal cell carcinoma (RCC), according to a study involving >4,500 individuals. Participants were ≥75 years of age with surgically-treated nonmetastatic T1a RCC. Investigators looked at the impact partial vs radical nephrectomy had on other-cause, cancer-specific, and 30-day mortality. Among the results:
- 42% of patients had partial nephrectomy.
- Those undergoing partial nephrectomy were 33% less likely than those who had radical nephrectomy to experience other-cause mortality.
- The favorable outcome was seen across all ages evaluated.
- Those in the partial nephrectomy group were 36% less likely to experience cancer-specific mortality.
- 30-day mortality rates did not differ.
Marchioni M, Preisser F, Bandini M, et al. Comparison of partial versus radical nephrectomy effect on other-cause mortality, cancer-specific mortality, and 30-day mortality in patients older than 75 years. [Published online ahead of print February 2, 2018]. Eur Urol Focus. doi:10.1016/j.euf.2018.01.007
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Must Reads in Renal Cell Carcinoma
First-line avelumab/axitinib for RCC benefits wide range of patients, Choueiri TK et al. GUCS 2019, Abstract 544.
One-fourth of placebo arm experience adverse events in RCC trials, Chacón M et al. JAMA Network Open. 2018 Dec 7. doi: 10.1001/jamanetworkopen.2018.5617
Strong link found between RCC and melanoma, Kim KB et al. Cancer Epidemiol. 2018 Oct 19;57:80-4