Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

High perirenal fat thickness predicts poor progression-free survival in patients with localized ccRCC

Huang H et al. Urologic Oncology: Seminars and Original Investigations 2018; 36: 157.e1-157.e6

Key clinical point: High perirenal fat thickness is an independent risk factor of tumor progression in localized clear cell renal cell carcinoma and this noninvasive preoperative parameter may help in risk stratification before surgery

Major finding: After a median of 38 months, 27 patients (21 with high perirenal fat thickness and 6 with low perirenal fat thickness) experienced tumor progression. High perirenal fat thickness was associated with a worse progression-free survival than low perirenal fat thickness (P = 0.005).

Study details: A retrospective, single-center analysis of 174 patients with localized localized clear cell renal cell carcinoma who had preoperative determinations of visceral fat area, perirenal fat thickness, and subcutaneous fat area. Kaplan-Meier curves were used to assess the differences in PFS between the high and the low PFT groups within sexes.

Disclosures: The researchers had no relevant financial disclosures.

Citation:

Huang H et al. Urologic Oncology: Seminars and Original Investigations 2018; 36: 157.e1-157.e6