Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

RNA editing contributes to myeloma pathogenesis

Teoh PJ et al. Blood. 2018;132(12):1304-17

Key clinical point: ADAR1-mediated editing of messenger RNA may be an important mechanism in multiple myeloma pathogenesis.

Major finding: ADAR1-mediated editing of NEIL1 leads to a weakened DNA base excision repair mechanism.

Study details: Experimental series using plasma samples from healthy volunteers and patients with multiple myeloma.

Disclosures: The study was supported by the National Research Foundation Singapore, the Singapore Ministry of Education, and the National University of Singapore. The authors reported having no competing financial interests.

Read the article here.


Teoh PJ et al. Blood. 2018;132(12):1304-17.