Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Angiogenesis, SOX11 expression in MCL positively correlate to increased inflammatory infiltrate

Key clinical point: Different immune inflammatory cells and blood microvessel composition are correlated to SOX11 expression.

Major finding: High SOX11 positivity (40%-100% of lymph node cells) is associated with increased angiogenesis and a high CD4+ and CD8+ T-cell infiltration.

Study details: Study of 3 subgroups of 63 MCL patients classified according to SOX11 expression as negative, light, and strong

Disclosures: The authors reported that the study did not receive outside funding and that they had no conflicts.


Annese T et al. Translational Oncology. 2020 13:100744.