Adults who survive childhood non-Hodgkin lymphoma (NHL) tend to experience impaired neurocognitive function that leads to lower social attainment and poor health-related life quality, according to a study involving 368 individuals. Investigators assessed neurocognitive ability, emotional distress, and health-related life quality in patients aged >18 years who survived NHL (n=187). Scores were compared with community controls (n=181) and population norms. Among the results:
- Survivors were an average of ~25 years from their diagnosis.
- 8 in every 10 received intrathecal chemotherapy; others received cranial radiation, high-dose methotrexate, or high-dose cytarabine.
- Intelligence and attention levels of survivors were normal.
- However, their memory, executive function, processing speed, and academics were impaired compared to population norms and controls.
- Treatment-related exposures were not linked with neurocognitive function.
- However, neurocognitive impairment was linked with lower educational attainment, unemployment, and occupational status.
- Slower processing speed and worse self-reported executive function were linked with depression symptoms and worse health-related life quality.
Ehrhardt M, Mulrooney D, Li C, et al. Neurocognitive, psychosocial, and quality-of-life outcomes in adult survivors of childhood non-Hodgkin lymphoma. [Published online ahead of print September 15, 2017]. Cancer. doi:10.1002/cncr.31019.