Clinical Edge

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Melflufen-dexamethasone active in patients with relapsed/refractory myeloma and EMD

Key clinical point: Melflufen plus dexamethasone is active in patients with relapsed/refractory multiple myeloma, whether or not they have extramedullary disease.

Major finding: The overall response rate was 23% in patients with extramedullary disease and 27% in those without.

Study details: A phase 2 trial of 130 patients, 44 with extramedullary disease and 86 without it.

Disclosures: The trial is sponsored by Oncopeptides. Dr. Richardson reported an advisory role and research funding from Oncopeptides.


Richardson PG et al. IMW 2019, Abstract OAB-086.