Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Benefits and Drawbacks Found for Risk-Based Lung Cancer Screening Tools

Key clinical point: Risk-based lung cancer screening could prevent more deaths than do current United States Preventive Services Task Force recommendations.

Major finding: The number of deaths per 100,000 population was reduced using risk-based lung cancer screening tools, compared with the USPSTF recommendations; however, few life-years were gained, and overdiagnosis was more common.

Study details: Smoking history of a simulated 1950 U.S. cohort from the Smoking History Generator.

Disclosures: One coauthor developed the PLCOm2012 model, but the model is available free to noncommercial users, and the investigator has received no money from its usage. No other conflicts of interest were reported.


ten Haaf K et al. J Natl Cancer Inst. 2019 Nov 29. doi: 10.1093/jnci/djz164.