The risk of large B-cell transformation is lower in people with new untreated nodular lymphocyte–predominant Hodgkin lymphoma (NLPHL) than it is in other low-grade lymphomas, according to an analysis involving 222 individuals.
Using the Mayo Clinic Lymphoma Database, investigators identified adults with NLPHL, and followed them for a median of 16 years. Participants averaged 40 years of age when diagnosed, and two-thirds were males. Among the results:
• The lymphomas of 17 patients transformed to diffuse large B-cell lymphoma.
• Median time to transformation was ~3 years.
• Transformation rate was 0.74 per 100 patient-years.
• Those who used chemotherapy previously had a significantly higher risk of transformation, as did those whose spleen was involved.
• 5-year overall survival was ~76% in those who lymphomas transformed.
• Transformation did not negatively impact survival when compared with those who did not experience transformation.
Citation: Kenderian S, Habermann T, Macon W, et al. Large B-cell transformation in nodular lymphocyte-predominant Hodgkin lymphoma: 40-year experience from a single institution. Blood. 2016;127(16):1960-1966. doi:http://dx.doi.org/10.1182/blood-2015-08-665505.