Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Diet appears to play an important role in response to anti-PD-1 cancer immunotherapy

Key clinical point: Diet appears to affect response to anti-PD-1 cancer immunotherapy.

Major finding: A high-fiber diet was associated with a fivefold greater likelihood of response to anti-PD-1 cancer immunotherapy (OR, 5.3).

Study details: A prospective study of 146 patients.

Disclosures: This study was sponsored by the Melanoma Research Alliance, the MD Anderson Melanoma Moonshot, the Miriam and Jim Mulva Fund for Melanoma Research, and the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation. Dr. Spencer disclosed that she is a contributor to U.S. patent application (PCT/US17/53.717) submitted by MD Anderson Cancer Center that covers methods of enhancing immune checkpoint blockade responses by modulating the microbiome.


Spencer C et al. AACR 2019, Abstract preview.