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Which Protocol is Best for Young People with HL?

Cancer; ePub 2017 Sep 13; Henderson, et al

Older adolescents and very young adults with Hodgkin lymphoma appear to have better outcomes when treated with a pediatric trial protocol than similarly-aged patients treated with an adult trial protocol, according to a study involving >500 individuals. Participants were between 17 and 21 years of age and had Hodgkin lymphoma. They were treated as part of either the Eastern Cooperative Oncology Group-American College of Radiology Imaging Network Intergroup adult study (n=114) or the pediatric Children's Oncology Group study (n=391). Investigators looked at failure-free and overall survival. Among the results:

  • The 5-year failure-free and overall survival rates were 68% and 89%, respectively, in the adult trial and 81% and 97%, respectively, in the pediatric study.
  • All subgroups treated in the adult trial had worse failure-free survival except for patients with stages 1 or 2 lymphoma without anemia.
  • Younger patients treated in the adult trial group had worse failure-free survival than 22- to 44-year-olds treated in the same trial.
  • Outcomes were similar regardless of age in the pediatric trial.

Citation:

Henderson T, Parsons S, Wroblewski K, et al. Outcomes in adolescents and young adults with Hodgkin lymphoma treated on US cooperative group protocols: An adult intergroup (E2496) and Children's Oncology Group (COG AHOD0031) comparative analysis. [Published online ahead of print September 13, 2017]. Cancer. doi:10.1002/cncr.30979.