Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Postop Taxane/Platinum Competes With Standard Therapy

Key clinical point: For patients with endometrial cancer at high risk of progression, receiving a combination of taxane and platinum chemotherapy after surgery offers similar efficacy and tolerability as doxorubicin and cisplatin, the standard therapy.

Major finding: The 5-year overall survival rate was 82.7% for doxorubicin/cisplatin, 86.1% for paclitaxel/carboplatin, and 88.1% for docetaxel/cisplatin (P = .67).

Study details: A prospective, phase 3 trial involving 788 patients with endometrial cancer at high risk of progression.

Disclosures: The study was funded by a Health Labour Sciences Research Grant with nonspecific funding from AstraZeneca, Eisai, Bristol-Myers Squibb, and others. The investigators reported financial relationships with Chugai, Sanofi, Takeda, AbbVie, and others.


Nomura H et al. JAMA Oncol. 2019 Mar 21. doi: 10.1001/jamaoncol.2019.0001.