Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Investigators recommend expanding testing for Lynch syndrome

Key clinical point: Investigators recommend considering genetic testing for Lynch syndrome in patients with endometrial cancer who have heterogeneous staining for DNA mismatch repair proteins.

Major finding: Three patients were found to have Lynch syndrome despite having immunohistochemical staining results that would have been reported as low risk.

Study details: Retrospective review of 455 patients who underwent hysterectomy for endometrial cancer.

Disclosures: The study was internally funded. Dr. Riedinger reported no conflicts of interest.


Riedeinger CJ et al. SGO 2020, Abstract 104.