Clinical Edge

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These Patients with Germ Cell Tumors Fare Worst

Ann Oncol; 2016 May; Adra, Althouse, Liu, et al

People with germ cell tumors (GCT) who had primary mediastinal nonseminomatous GCTs or brain metastasis had a higher risk of death than their counterparts, according to a retrospective analysis of 273 individuals.

All participants were treated with cisplatin–etoposide-based chemotherapy. Investigators looked at significant predictors of disease progression and mortality. Among the results:

• 5-year progression-free survival was 58%; overall survival was 73%.

• Liver metastasis, brain metastasis, PMNSGCT, and elevation in logarithmic β-hCG were linked with disease progression.

• People with PMNSGCT were 4.6 times more likely to die; those with brain metastasis were 3.3 times more likely to do so.

Citation: Adra N, Althouse S, Liu H, et al. Prognostic factors in patients with poor-risk germ-cell tumors: A retrospective analysis of the Indiana University experience from 1990 to 2014. Ann Oncol. 2016;27(5):875-879. doi:10.1093/annonc/mdw045.