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Pembrolizumab in advanced clear cell RCC

McDermott DF et al. ASCO 2018 (annual meeting of the American Society of Clinical Oncology), Abstract 4500.

Key clinical point: Pembrolizumab monotherapy shows promising efficacy and tolerability in advanced clear cell renal cell carcinoma (accRCC).

Major finding: Overall response rate was 38%.

Study details: The phase 2 KEYNOTE-427 trial of 110 patients from one of two study cohorts.

Disclosures: Merck sponsored the study. Dr. McDermott reported consulting or advisory roles with Array BioPharma, Bristol-Myers Squibb, Exelixis, Genentech/Roche, Merck, Novartis, Pfizer, and X4 Pharma. His institution has received research funding from Prometheus Laboratories.

Source: McDermott DF et al. ASCO 2018 (annual meeting of the American Society of Clinical Oncology), Abstract 4500.

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Citation:

McDermott DF et al. ASCO 2018 (annual meeting of the American Society of Clinical Oncology), Abstract 4500.

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