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Leptin expression may aid in differentiation of renal lesions

Gobe G et al. Pathology. 2018 Aug;50(5):504-10

Key clinical point: Measuring leptin expression could help differentiate benign renal oncocytomas from chromophobe renal cell carcinoma (RCC).

Major finding: Nuclear leptin intensity was significantly increased for renal oncocytomas versus eosinophilic variants of chromophobe RCC (P = 0.016).

Study details: Evaluation of 75 archived tissue samples, including 30 chromophobe RCC specimens, 15 renal oncocytomas, and 30 clear cell RCCs, along with matched, noncancerous kidney tissue specimens.

Disclosures: The University of Malaya, Kuala Lumpur, Malaysia, funded the study. The authors stated that they had no conflicts of interest.

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Gobe G et al. Pathology. 2018 Aug;50(5):504-10