Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Leptin expression may aid in differentiation of renal lesions

Gobe G et al. Pathology. 2018 Aug;50(5):504-10

Key clinical point: Measuring leptin expression could help differentiate benign renal oncocytomas from chromophobe renal cell carcinoma (RCC).

Major finding: Nuclear leptin intensity was significantly increased for renal oncocytomas versus eosinophilic variants of chromophobe RCC (P = 0.016).

Study details: Evaluation of 75 archived tissue samples, including 30 chromophobe RCC specimens, 15 renal oncocytomas, and 30 clear cell RCCs, along with matched, noncancerous kidney tissue specimens.

Disclosures: The University of Malaya, Kuala Lumpur, Malaysia, funded the study. The authors stated that they had no conflicts of interest.

Read the article.

Citation:

Gobe G et al. Pathology. 2018 Aug;50(5):504-10

This Week's Must Reads

Inadequate emergency care a challenge for rural pediatric patients, Walling EB et al. J Oncol Pract. 2019 Jan 31. doi: 10.1200/JOP.18.00115.

QC measures improve with CMS Oncology Care Model, Rocque G et al. J Oncol Pract. 2019. doi: 10. 1200/JOP.18.00390.

Women less likely to receive industry funds, Weng JK et al. JAMA Netw Open. 2019 Jan. 25. doi: 10.1001/jamanetworkopen.2018.7377.

A shift in Medicare drug coverage may boost costs for patients, Hwang TJ et al. JAMA Int Med. 2019. doi: 10.1001/jamainternmed.2018.6417.

President Trump requests $500 million for pediatric cancer, Trump D. State of the Union Address, Feb. 5, 2019.

Must Reads in Genitourinary Cancer

Obesity-related cancers such as kidney cancer rising among young adults, Sung H et al. Lancet Public Health. 2019 Feb 4.

Leptin expression may aid in differentiation of renal lesions, Gobe G et al. Pathology. 2018 Aug;50(5):504-10

Hypofractionated radiation offers 'tailored treatment' approach to RCC mets, Felice F et al. Crit Rev Oncol Hematol. 2018 Aug 1. doi: 10.1016/j.critrevonc.2018.06.002.

Concern over SREs rises with increasing incidence of metastatic RCC, Umer M et al. Ann Med Surg. 2018 Jan 21. doi: 10.1016/j.amsu.2018.01.002