Key clinical point: Measuring leptin expression could help differentiate benign renal oncocytomas from chromophobe renal cell carcinoma (RCC).
Major finding: Nuclear leptin intensity was significantly increased for renal oncocytomas versus eosinophilic variants of chromophobe RCC (P = 0.016).
Study details: Evaluation of 75 archived tissue samples, including 30 chromophobe RCC specimens, 15 renal oncocytomas, and 30 clear cell RCCs, along with matched, noncancerous kidney tissue specimens.
Disclosures: The University of Malaya, Kuala Lumpur, Malaysia, funded the study. The authors stated that they had no conflicts of interest.
Gobe G et al. Pathology. 2018 Aug;50(5):504-10