Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Adjuvant radiotherapy no better than salvage post prostatectomy

Key clinical point: Men who undergo radical prostatectomy can be safely spared from adjuvant radiotherapy.

Major finding: There were no significant differences in outcomes between men assigned to adjuvant radiotherapy and observation with salvage radiation.

Study details: Randomized trial in 1,369 men and meta-analysis of pooled results for 2,151 men.

Disclosures: The RADICALS-RT trial is supported by Cancer Research UK and the Medical Research Council UK. Dr. Parker said he had no disclosures relevant to the trial. ARTISTIC is funded by the Medical Research Council. Dr. Vale reported having no disclosures. Dr. De Meerleer reported speaker fees, advisory board activities, and scientific grants not related to the studies.


Parker C et al. and Vale C et al. ESMO 2019. Abstracts LBA49_PR and LBA48_PR.