Clinical Edge

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Postcolonoscopy Colorectal Cancers Had Unique Features

Key clinical point: Postcolonoscopy colorectal cancers were more likely to arise in the proximal colon and to show microsatellite instability.

Major finding: In all, 64% of postcolonoscopy colorectal cancers were located in the proximal colon, compared with 44% of detected colorectal cancers (P = .016). Microsatellite instability was detected in 32% of postcolonoscopy colorectal cancers, compared with 13% of detected colorectal cancers (P = .005).

Study details: Retrospective cross-sectional study comparing 84 postcolonoscopy colorectal cancer cases with 84 detected colorectal cancers.

Disclosures: Funders included the American College of Gastroenterology, the National Cancer Institute, the Huntsman Cancer Foundation, the University of Utah, and the Utah Department of Health. Dr. Samadder reported consulting relationships with Cancer Prevention Pharmaceuticals and Janssen Research and Development. The other researchers reported having no conflicts of interest.


Samadder NJ et al. Clin Gastroenterol Hepatol. 2019 Mar 28. doi: 10.1016/j.cgh.2019.02.040.