Key clinical point: CRC screening by any of the four common methodologies only slightly reduced the incidence of CRC for patients with normal risk.
Major finding: For individuals aged 50-79 with no symptoms and an estimated 15-year CRC risk below 3%, no screening is recommended.
Study details: The MAGIC group in collaboration with BMJ did a systematic review of CRC screening trials that involved almost 1.4 million patients.
Disclosures: The authors had no financial conflicts of interest.
BMJ 2019;367:l5515. doi: 10.1136/bmj.l5515.