Clinical Edge

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Lynch Syndrome Screening Shows Low Efficiency in Elderly

Key clinical point: A retrospective study suggests universal screening for Lynch syndrome in elderly patients with newly diagnosed colorectal cancer (CRC) may be unnecessary.

Major finding: Of 63 Lynch syndrome cases detected by universal screening, 5 (7.9%) were identified over age 70 years and 1 (1.6%) was detected over age 80 years.

Study details: A retrospective analysis of 3,891 patients with newly diagnosed CRC who were screened for Lynch syndrome.

Disclosures: The study was funded by Kaiser Permanente Northern California. The authors reported financial affiliations with Bayer, Clinical Genomics, Covidien, Exact Sciences, Motus GI, Quorum, Universal DX, and the National Cancer Institute.


Li D et al. Ann Intern Med. 2019 Jun 11. doi: 10.7326/M18-3316.