Clinical Edge

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Direct-Acting Antiviral Treatment May Reduce Mortality in Patients With HCC History

Key clinical point: For patients with a complete response following treatment for hepatitis C virus (HCV)–related hepatocellular carcinoma (HCC), treatment with direct-acting antiviral therapy was linked to significantly reduced mortality compared with no such treatment.

Major finding: Treatment with DAA therapy was associated with improved overall survival, according to results of multivariable analysis, with a hazard ratio of 0.54 (95% confidence interval, 0.33-0.90).

Study details: Multicenter, retrospective North American cohort study of 797 patients with HCV-related HCC who achieved complete response following treatment.

Disclosures: Dr. Singal reported disclosures related to AbbVie, Bayer, BMS, Eisai, Exact Sciences, Exelixis, Genentech, Gilead FOCUS, Glycotest, GRAIL, Merck, Roche, TARGET Pharmasolutions, and Wako Diagnostics.


Singal AG et al. The Liver Meeting 2019, Abstract 199.