Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Unique Mutations Differentiate Ovarian DLBCL From the Extranodal Form

Key clinical point: Ovarian and extranodal DLBCL show key similarities and differences in morphology, metabolism, and genotypes.

Major finding: NOTCH3 and HDAC4 mutations were found only in ovarian DLBCL but not in conventional DLBCL.

Study details: First time comparison of the clinical, morphological, immunohistochemical, and genotypic characteristics of 9 ovarian diffuse large B-cell lymphoma (DLBCL) cases to extranodal DLCBL controls.

Disclosures: Support was from the National Natural Science Foundation of China. The authors reported that they had no conflicts.


Hu H et al. Pathology. 2020. 52(2):206–212.