Clinical Edge

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Study Links DLBCL, MZL in Sjogren’s Syndrome

Key clinical point: A small case series suggests a clonal relationship exists between diffuse large B-cell lymphoma (DLBCL) and marginal zone lymphoma (MZL) in patients with Sjogren’s syndrome.

Major finding: After fragment analysis, matching clonal gene rearrangement patterns were found in 5 of 6 tumor pairs, despite varying localization of both lymphomas in these cases.

Study details: A retrospective case series of 6 patients with Sjogren’s syndrome and both DLBCL and MZL.

Disclosures: No funding sources were reported. The authors reported having no conflicts of interest.


Gorodetskiy VR et al. Rheumatol Int. 2019 Nov 9. doi: 10.1007/s00296-019-04470-x.