Clinical Edge

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Study Identifies Novel Drug Target in DLBCL, MCL

Key clinical point: Pre-clinical data suggests maternal embryonic leucine zipper kinase (MELK) may be a novel drug target in diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL).

Major finding: In cellular studies, the MELK inhibitor OTSSP167 demonstrated strong anti-cancer activity in several lymphoma cell lines.

Study details: A pre-clinical study examining the effects of MELK as a novel drug target in DLBCL and MCL.

Disclosures: The authors reported having no conflicts of interest.


Maes A et al. Blood Cancer J. 2019 Nov 18. doi: 10.1038/s41408-019-0249-x.