Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Diabetes plus weight loss equals increased risk of pancreatic cancer

Key clinical point: Recent-onset diabetes accompanied by weight loss is associated with an increased risk of developing pancreatic cancer.

Major finding: Patients with diabetes and a weight loss of more than 8 pounds (164 incident cases per 100,000 person years) had a much higher incidence of pancreatic cancer, compared with patients with neither (16 incident cases per 100,000 person-years).

Study details: An analysis of decades of data from 112,818 women in the Nurses’ Health Study and 46,207 men in the Health Professionals Follow-Up Study.

Disclosures: The authors noted numerous potential conflicts of interest, including receiving grants and personal fees from various initiatives, organizations, and pharmaceutical companies.


Yuan C et al. JAMA Oncol. 2020 Aug 13. doi: 10.1001/jamaoncol.2020.2948.