Clinical Edge

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Reports suggest possible in utero transmission of novel coronavirus 2019

Key clinical point: Reports of three neonates whose mothers had COVID-19 raise questions about whether the infants may have been infected in utero.

Major finding: The neonate described in the research letter and two of the six neonates in the retrospective study had elevated IgM antibodies to SARS-CoV-2.

Study details: A research letter detailing an infant whose mother had COVID-19 and a retrospective study of six infants whose mothers had COVID-19.

Disclosures: Dr. Dong and associates had no conflicts of interest. Their work was supported by the National Key Research and Development Project and others. Dr. Zeng and colleagues had no relevant financial disclosures. Their study was supported by grants from the National Natural Science Foundation of China and Zhongnan Hospital.


Dong L et al. JAMA. 2020 Mar 26. doi: 10.1001/jama.2020.4621; Zeng H et al. JAMA. 2020 Mar 26. doi: 10.1001/jama.2020.4861.