Stereotactic radiosurgery (SRS) plus whole brain radiation therapy (WBRT) improves survival in certain patients with brain metastases, according to a Cochrane review of 3 trials. Among the findings, based on moderate quality evidence:
- Overall, participants who underwent WBRT and SRS did not survive longer than participants who were treated with WBRT alone.
- Patients who were able to perform activities of daily life in a highly functional way, as well as those with a single metastasis, survived longer after combination therapy.
- Those given combined treatment experienced better local control and performance status, and used steroids less frequently.
Patil C, Pricola K, Sarmiento J, Garg S, Bryant A, Black K. Whole brain radiation therapy (WBRT) alone versus WBRT and radiosurgery for the treatment of brain metastases. Cochrane Database of Syst Rev. 2017, Issue 9. Art. No.: CD006121. doi:10.1002/14651858.CD006121.pub4.
This Week's Must Reads
Intensity modulated radiation therapy may be preferable in children with extremity nonrhabdomyosarcoma soft-tissue sarcomas, Source: Rao A et al. Intl J Rad Oncology*Biology*Physics; Jan. 2019, 38-44. https://doi.org/10.1016/j.ijrobp.2018.09.005
TAO: Nonwhite ethnicity, limb infection predict poor prognosis, Le Joncour A et al. Arthritis Rheumatol. 2018;70(Suppl 10): Abstract 1885
Thrombolysis for acute ischemic stroke safe in GI malignancy, Inohara T et al. Circulation. 2018 Nov 6;138[suppl 1], Abstract A12291
Ten years of anastrozole boosts disease-free survival, Ohtani S et al. SABCS 2018, Abstract GS3-04
Outcomes better in TNBC with adjuvant chemotherapy within 30 days of surgery, Morante Z et al., SABCS 2018 Abstract GS2-05
Must Reads in CNS/Brain Cancer
Prophylactic cranial irradiation boosts OS in advanced NSCLC , Arrieta O et al. WCLC 2018, Abstract MA08.02.
Nivolumab plus ipilimumab ups survival in melanoma patients with brain mets, Tawbi HA et al. N Engl J Med. 2018 Aug 23. doi: 10.1056/NEJMoa1805453
Cochrane on Radiosurgery, Radiation for Brain Ca, Cochrane; 2017 Sep 25; Patil, Pricola, et al
FDA Approves First Biosimilar to Treat Cancer, FDA news release; 2017 Sep 14
Chemo Regimens for High-Grade Gliomas, Cochrane; 2017 Jul 26; Parasramka, Talari, et al