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Oxidative stress linked to cytogenetic abnormalities in CLL

Key clinical point: B-CLL patients had increased serum oxidative stress markers and an imbalance in their antioxidant defense system.

Major finding: The odds of a cytogenetic abnormality increased by a factor of 1.88 (P = .004) for every one-unit increase in serum conjugated diene (CD) level.

Study details: 64 B-cell CLL patients were grouped according to disease stage, mutated/unmutated IGHV genes, and presence/absence of cytogenetic abnormalities.

Disclosures: The research was unsponsored and the authors reported having no conflicts.

Citation:

Zhevak T et al. Exp Mol Patholo. 2020 Oct;16:104524 doi: 10.1016/j.yexmp.2020.104524.