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Interleukin-27 increased cytotoxic effects of bone marrow NK cells in CLL

Key clinical point: Interleukin-27 was able to decrease cytotoxic effects of bone marrow natural killer cells in CLL.

Major finding: BM-NK cell cytotoxicity was significantly increased in cells treated with interleukin 27 (P < .001).

Study details: Bone marrow aspirates and peripheral blood samples were obtained from 12 untreated CLL patients and tested in vitro.

Disclosures: The research was supported by Semnan (Iran) University of Medical Sciences. The authors reported that they had no conflicts of interest.


Hemati M et al. Int Immunopharmacol. 2020;