Clinical Edge

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Five prognostic indexes come up short for planning early CLL treatment

Key clinical point: None of the indexes was able to predict with total precision the clinical evolution of chronic lymphocytic leukemia.

Major finding: The most accurate score in predicting time to first therapy was IPS-A, followed by CLL-01, and CLL-IPI.

Study details: Five prognostic indexes were applied to 428 early-stage chronic lymphocytic leukemia patients from a multicenter Spanish database with clinical and biological information.

Disclosures: The study was supported by grants from the Spanish government and a variety of nonprofit institutions. The authors reported no commercial disclosures.


Gascon y Marín IG et al. Clin Lymphoma Myeloma Leuk. 2020 Apr 13. doi: 10.1016/j.clml.2020.03.003.