Clinical Edge

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Antihistamines synergistically induce CLL cell death with TK inhibitors

Key clinical point: Clemastine was the most effective at inducing chronic lymphocytic leukemia cell death.

Major finding: Antihistamines induced synergistic cytotoxicity with the tyrosine kinase inhibitor, ibrutinib, but not with chemotherapy.

Study details: Blood from chronic lymphocytic leukemia patients and age-matched healthy donors was collected, treated, and compared with two malignant B-cell lines.

Disclosures: The study was supported by grants from the Cancer Research Society and the CancerCare Manitoba Foundation. The authors reported that they had no conflicts.


Chanas-Larue A et al. Leuk Res. 2020 Jul 17. doi: 10.1016/j.leukres.2020.106423.