Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

New Toxicity Subscale Measures QOL in Cancer Patients on Checkpoint Inhibitors

Key clinical point: A new tool specifically designed to evaluate immune checkpoint inhibitor–related toxicity, developed based on direct patient involvement, picks up on cutaneous and other side effects.

Major finding: The toxicity subscale asks patients to rate 25 items on a scale of 0 (not at all) to 4 (very much).

Study details: Data based on input from 37 cancer patients being treated with immune checkpoint inhibitors and 16 physicians.

Disclosures: The study was supported by a grant from the University of Toronto. Authors of the study provided disclosures related to Merck, Bristol-Myers Squibb, Karyopharm, Boston Biomedical, Novartis, Genentech, Hoffmann La Roche, GlaxoSmithKline, and others.


Hansen AR et al. Cancer. 2020. doi: 10.1002/cncr.32692.