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CLL, GVHD may raise risk for skin cancer after allo-HCT

Key clinical point: Chronic graft-versus-host disease and prior chronic lymphocytic leukemia CLL were associated with various forms skin cancer after allogeneic transplant.

Major finding: Prior CLL (hazard ratio, 2.2; 95% CI, 1.3-3.7), chronic graft-versus-host-disease (HR, 3.1; 95% CI, 1.7-5.4), and age at transplant of more than 60 years (HR, 10.8; 95% CI, 3.3-35.6) were all linked to an increased risk for squamous cell carcinomas.

Study details: A retrospective analysis of 119 patients who developed secondary skin cancer after undergoing allogeneic transplant.

Disclosures: The study was supported by the Skin Cancer Foundation, Women’s Dermatologic Society, Harvard Catalyst, and Harvard University. The authors reported having no conflicts of interest.