Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

With a positive sentinel node, RT better than surgery

Rutgers EJT et al. SABCS 2018, Abstract GS4-01

Key clinical point: In patients with a positive sentinel node, axillary radiation has similar efficacy to axillary lymph node dissection and less morbidity.

Major finding: Compared with axillary lymph node dissection, axillary radiation therapy had a similar 10-year cumulative incidence of axillary recurrence (1.82% vs. 0.93%; P = .365) and half the 5-year rate of lymphedema (14.6% vs. 29.4%; P less than .0001).

Study details: A phase 3, noninferiority, randomized, controlled trial among 1,425 women with early-stage breast cancer and a positive sentinel node.

Disclosures: Dr. Rutgers reported that he had no relevant conflicts of interest. The study was supported by the European Organization for Research and Treatment of Cancer Charitable Trust.

Read the article here.


Rutgers EJT et al. SABCS 2018, Abstract GS4-01.