Key clinical point: In patients with a positive sentinel node, axillary radiation has similar efficacy to axillary lymph node dissection and less morbidity.
Major finding: Compared with axillary lymph node dissection, axillary radiation therapy had a similar 10-year cumulative incidence of axillary recurrence (1.82% vs. 0.93%; P = .365) and half the 5-year rate of lymphedema (14.6% vs. 29.4%; P less than .0001).
Study details: A phase 3, noninferiority, randomized, controlled trial among 1,425 women with early-stage breast cancer and a positive sentinel node.
Disclosures: Dr. Rutgers reported that he had no relevant conflicts of interest. The study was supported by the European Organization for Research and Treatment of Cancer Charitable Trust.
Rutgers EJT et al. SABCS 2018, Abstract GS4-01.
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Advanced age not linked with risk from nipple-sparing mastectomy, Cox S et al. and Bartholomew AJ et al. Session SF310 ACS Clinical Congress 2018