Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Personalized cancer vaccine may enhance checkpoint inhibitor activity

Key clinical point: Combining a personalized cancer vaccine known as RO7198457 with the immune checkpoint inhibitor atezolizumab induced neoantigen-specific immune responses in most patients with advanced solid tumors.

Major finding: Ex vivo T-cell responses occurred in 73% of patients evaluated (46/63). However, there were only two clinical responses, including one complete response.

Study details: A phase 1b study including 142 patients exposed to the combination of RO7198457 and atezolizumab.

Disclosures: The study was funded by Genentech and BioNTech. The presenting author reported disclosures related to Roche/Genentech, Basilea Pharmaceutica, and Genmab.


Lopez J et al. AACR 2020, Abstract CT301.