Key clinical point: The cancer genome varies widely between individuals with the same cancer type and during the course of tumor development.
Major finding: On average, patients with 1 of 38 cancer types have four to five driver mutations.
Study details: Whole-genome sequencing of tumors from 2,658 donors with 38 malignant tumor types.
Disclosures: The Pan-Cancer Analysis of Whole Genomes was a collaborative multinational effort with multiple funding sources.
Nature. 2020 Feb 5. https://www.nature.com/collections/pcawg/