Clinical Edge

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Gene signature found similarly prognostic in ILC and IDC

Key clinical point: The MammaPrint gene signature’s prognostic performance in invasive lobular carcinoma (ILC) is similar to that in invasive ductal carcinoma (IDC).

Major finding: The 5-year distant metastasis–free survival rate with a MammaPrint-classified high genomic risk was 92.1% in women with IDC vs. 88.1% in women with ILC, with overlapping 95% confidence intervals.

Study details: An exploratory subgroup analysis of 5,313 women with early-stage breast cancer (487 with ILC and 4,826 with IDC) participating in a phase 3 randomized controlled trial of risk-guided adjuvant chemotherapy (MINDACT trial).

Disclosures: The study was funded with support from the Breast Cancer Research Foundation. Dr. Metzger disclosed consulting fees from AbbVie, Genentech, Roche, and Pfizer.


Metzger O et al. EBCC-12 Virtual Conference. Abstract 6.