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With Endocrine Therapy, Attitude Counts

Breast Cancer Res Treat; ePub 2016 Apr 16; Hershman, et al

Women with a more positive attitude about endocrine therapy, better quality of life, and more treatment satisfaction are less likely to be non-adherent than those with intrusive/avoidant thoughts, according to a study involving 523 individuals.

Looking for factors related to nonadherence, investigators interviewed participants every 6 months using several assessments. Among the results:

• 18% were nonadherent over a 2-year follow-up. They tended to be white, have stage 1 disease, and on an aromatase inhibitor.

• Women in the highest income category were 57% less likely to be nonadherent.

• Quality of life and attitudes about endocrine therapy at baseline were linked with later nonadherence.

The authors concluded that interventions that improve psychosocial well-being can increase adherence.

Citation: Hershman D, Kushi L, Hillyer G, et al. Psychosocial factors related to non-persistence with adjuvant endocrine therapy among women with breast cancer: The breast cancer quality of care study (BQUAL). [Published online ahead of print April 16, 2016]. Breast Cancer Res Treat. doi:10.1007/s10549-016-3788-x.