Women with a more positive attitude about endocrine therapy, better quality of life, and more treatment satisfaction are less likely to be non-adherent than those with intrusive/avoidant thoughts, according to a study involving 523 individuals.
Looking for factors related to nonadherence, investigators interviewed participants every 6 months using several assessments. Among the results:
• 18% were nonadherent over a 2-year follow-up. They tended to be white, have stage 1 disease, and on an aromatase inhibitor.
• Women in the highest income category were 57% less likely to be nonadherent.
• Quality of life and attitudes about endocrine therapy at baseline were linked with later nonadherence.
The authors concluded that interventions that improve psychosocial well-being can increase adherence.
Citation: Hershman D, Kushi L, Hillyer G, et al. Psychosocial factors related to non-persistence with adjuvant endocrine therapy among women with breast cancer: The breast cancer quality of care study (BQUAL). [Published online ahead of print April 16, 2016]. Breast Cancer Res Treat. doi:10.1007/s10549-016-3788-x.