Clinical Edge

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Early screening may halve breast cancer mortality in childhood cancer survivors

Key clinical point: Initiating breast cancer screening at 25-30 years of age may sharply reduce disease mortality among women who have received chest radiotherapy for childhood cancer.

Major finding: When compared with no screening, starting annual mammography with MRI at age 30 averted 55%-69% of breast cancer deaths, and starting MRI alone at age 30 averted 54%-60% of breast cancer deaths.

Study details: A modeling study using data from the Childhood Cancer Survivor Study and other published sources, for women aged 20 years treated for childhood cancer during 1970-1986.

Disclosures: The research was supported by grants from the National Cancer Institute, American Cancer Society, and American Lebanese Syrian Associated Charities. Authors disclosed relationships with GE Healthcare and Biovector.


Yeh JM et al. Ann Intern Med. 2020 Jul 7. doi: 10.7326/M19-3481.