Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Cancer Burden: Multiple Metrics Needed to Clarify the Big Picture

Key clinical point: Discerning the factors influencing population cancer burden requires joint consideration of multiple metrics.

Major finding: Epidemiologic signatures were desirable (e.g., CML, colorectal cancer), were undesirable (e.g., thyroid cancer, kidney cancer, melanoma), or presented mixed signals (e.g., breast cancer, prostate cancer).

Study details: An analysis of data from SEER and National Vital Statistics for the years 1975-2015, assessing patterns in incidence, mortality, and metastatic incidence for 11 cancers individually and all cancers combined.

Disclosures: Dr. Welch reported that he had no relevant disclosures. The analysis did not receive any specific funding.


Welch HG et al. N Engl J Med. 2019;381:1378-86. doi: 10.1056/NEJMsr1905447.