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Restricted platelet transfusion yields better outcomes in preterm infants

Curley A et al. N Engl J Med. 2018 Nov 2. doi: 10.1056/NEJMoa1807320

Key clinical point: A lower threshold for platelet transfusions in preterm infants with severe thrombocytopenia is associated with better outcomes.

Major finding: The odds of new major bleeding or death were 57% higher in preterm infants who received a platelet transfusion at a higher threshold of 50,000 per mm3 than at a lower threshold of 25,000 mm3 (P = .02).

Study details: Randomized study in 660 preterm infants with severe thrombocytopenia.

Disclosures: The study was supported by the National Health Service Blood and Transplant Research and Development Committee, and other foundations. Authors reported financial disclosures related to Sanquin and Cerus.

Read the article here.


Curley A et al. N Engl J Med. 2018 Nov 2. doi: 10.1056/NEJMoa1807320.