Key clinical point: A lower threshold for platelet transfusions in preterm infants with severe thrombocytopenia is associated with better outcomes.
Major finding: The odds of new major bleeding or death were 57% higher in preterm infants who received a platelet transfusion at a higher threshold of 50,000 per mm3 than at a lower threshold of 25,000 mm3 (P = .02).
Study details: Randomized study in 660 preterm infants with severe thrombocytopenia.
Disclosures: The study was supported by the National Health Service Blood and Transplant Research and Development Committee, and other foundations. Authors reported financial disclosures related to Sanquin and Cerus.
Curley A et al. N Engl J Med. 2018 Nov 2. doi: 10.1056/NEJMoa1807320.