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Past Donor Pregnancy, Sex Do Not Affect Transfusion-Related Mortality

Key clinical point: There was no significant association between either blood donor sex or prior pregnancy and in-hospital mortality of red blood cell transfusion recipients.

Major finding: The hazard ratio estimates for in-hospital mortality for each unit transfused from a previously pregnant donor ranged from 1.00-1.01 in the three cohorts. Similarly, the HR estimates ranged from 0.99-1.00 for female donors in the three cohorts and 0.99-1.02 for sex discordant donors.

Study details: A retrospective analysis of 1,047,382 red blood cell transfusion recipients across three separate cohorts.

Disclosures: The study was funded by the National Heart, Lung, and Blood Institute. The authors reported financial disclosures related to the National Institutes of Health, RTI International, Cerus, AABB, Creative Testing Solutions, and the Nordic Cancer Union.


Edgren G et al. JAMA. 2019 Jun 11. doi: 10.1001/jama.2019.7084.