Key clinical point: A wide variety of genetic mutations were found apart from the routine intron 22 inversion mutation in a cohort of Vietnamese patients with hemophilia A.
Major finding: Two novel F8 mutations were detected that resulted in a severe clinical phenotype.
Study details: A genetic analysis of 103 patients with hemophilia A.
Disclosures: The study was supported by grant funding from the Ministry of Health of Vietnam. The authors reported having no conflicts of interest.
Luu DV et al. Haemophilia. 2019 Mar 26..