Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Fresh RBCs offer no benefit over older cells in pediatric ICU

Key clinical point: Fresh RBCs were neither safer nor more effective than standard stored RBCs when transfused into critically ill children.

Major finding: There were no significant differences in the incidence of organ dysfunction between patients randomized to transfused fresh RBCs or standard RBCs (20.2% vs. 18.2%).

Study details: A randomized, controlled trial in 1,461 children in an intention-to-treat analysis.

Disclosures: ABC PICU was supported by Washington University, St. Louis; the National Heart, Lung, and Blood Institute; the Canadian and French governments; and other groups. Dr. Spinella reported having no relevant conflicts of interest.


Spinella P et al. AABB 2019, Abstract PL3-MN4-32.