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Consider This in Patients with TMA—and Vice Versa

J Clin Apher; ePub 2018 Jan 26; Bade, Giffi, et al

HIV should be considered in people with of thrombotic microangiopathy (TMA), and vice versa, researchers concluded after conducting a study involving 102 individuals. Participants underwent therapeutic plasma exchange (TPE) for TMA between 2000 and 2012. Investigators compared results in patients known to be HIV-positive with those who were HIV-negative. Among the results:

  • 27% of patients were HIV-positive.
  • They had a median viral load of 89,500 copies/mL and median CD4 count of 58 cells/µL.
  • 61% of HIV-positive patients had concurrent infections, vs 24% of HIV-negative individuals.
  • A higher proportion of HIV-positive patients had platelet counts <10,000/mcL.
  • Number of TPE procedures to reach remission, remission rate, mortality, and relapse rate were similar in both groups.

Citation:

Bade N, Giffi V, Baer M, Zimrin A, Law J. Thrombotic microangiopathy in the setting of human immunodeficiency virus infection: High incidence of severe thrombocytopenia. [Published online ahead of print January 26, 2018]. J Clin Apher. doi:10.1002/jca.21615.